(CIT): The major focus of research in the Palmiter laboratory involves analysis of the developmental and behavioral consequences of inactivating mouse genes necessary for neurotransmitter signaling. The lab has produced knockout mice that cannot produce dopamine, norepinephrine or neuropeptide Y. Current efforts are centered on four areas. First, the lab is exploring the relationship between dopamine and reward. The lab uses viral transduction to restore dopamine signaling in specific brain regions to gain insight into where in the brain dopamine is required for certain behaviors. The second area focuses on the role of norepinephrine in regulating various processes including, sleep, withdrawal from morphine addiction and glucose homeostasis. For more information, visit Richard Palmiter, NIH Neuroscience Seminar Series.