Dimethyltryptamine (DMT) also known as NN-dimethyltryptamine is a naturally-occurring tryptamine and potent psychedelic drug found not only in many plants but also in trace amounts in the human body where its natural function is undetermined. Structurally it is analogous to the neurotransmitter serotonin and other psychedelic tryptamines such as 5-MeO-DMT and 4-HO-DMT. DMT is created in small amounts by the human body during normal metabolism by the enzyme tryptamine-N-methyltransferase. Many cultures indigenous and modern ingest DMT as a psychedelic in extracted or synthesized forms. Pure DMT at room temperature is a clear or white to yellowish-red crystalline solid. DMT was first chemically synthesized in 1931.Inhaled: If DMT is smoked the maximal effects last for a short period of time (5 to 30 minutes dose-dependent). The onset after inhalation is very fast (less than 45 seconds) and maximal effects are reached within about a minute. In the 1960s some reportedly referred to DMT as "The businessmans trip" due to the relatively short duration of vaporized insufflated or injected DMT. Smoking DMT is extremely difficult due to the overwhelming harshness of the smoke produced. Many users cough the smoke thus wasting the drug vaporized. The taste and smell of the smoke is reminiscent of burning plastic or mothballs.Insufflation: When DMT is insufflated (snorted through the nostrils) the duration is markedly increased and some users report diminished euphoria for increased "spiritual" qualities of effect.Injection: Injected DMT produces an experience similar to inhalation in duration intensity and characteristics.Oral ingestion: DMT which is broken down by the digestive enzyme monoamine oxidase is practically inactive if taken orally unless combined with a MAOI. The traditional South American ayahuasca or yage is a tea mixture containing DMT and a MAOI. There are a number of admixtures to this brew but most commonly it is simply the leaves of Psychotria viridis (con...