BLOOD WORK, starring Clint Eastwood as retired FBI agent Terry McCaleb, is a mystery thriller about a serial killer whose latest victim was the organ donor responsible for McCaleb’s recent heart transplant. When the victim's sister, Graciella (Wanda de Jesus), delivers this strange news to him and asks for his help, he has no choice but to answer her call, against his doctor's wishes. While frisky LAPD officers try to keep McCaleb away because his top-notch profiling skills make their efforts seem feeble, and McCaleb's physical strength and stamina are limited more than ever before, it seems as if the case is destined to go unsolved. But McCaleb's conscience weighs too heavily upon him to let the murderer go free, and the only way to clear his mind and find peace is to throw his full energy into the investigation. McCaleb lives on a boat and is well-acquainted with a lazy, drunken young man, Buddy (Jeff Daniels), who lives on a boat in the same berth, so he enlists Buddy as his driver and assistant. What ensues is an excellent police drama that leads McCaleb through an extensive process of analyzing evidence, questioning people related to the crimes, and breaking codes, and results in a chilling and totally unexpected climax.