People with chronic myeloid leukemia, or chronic myelogenous leukemia, or CML, are usually treated with a drug called imatinib, or Gleevec ®. It is especially effective in the chronic phase of the disease. Sometimes patients have problems with severe side effects. This is known as intolerance. Other times, people experience resistance. This can be primary or secondary resistance. When this occurs, there are a variety of treatment options. These include a stem cell or bone marrow transplant. Doctors sometimes increase the dose of the medication. Other times they decrease the dose. Sometimes the