Clive (Academy Award-winner Adrien Brody) and Elsa (Academy Award-nominee Sarah Polley) are young, brilliant and ambitious. The new animal species they engineered have made them rebel superstars of the scientific world. In secret, they introduce human DNA into the experiment. The result is something that is greater than the sum of its parts: a female animal-human hybrid that may be a step up on the evolutionary ladder. Clive and Elsa think they may have designed the perfect organism, until she makes a final shocking metamorphosis that could destroy them... into a deadly creature.