In the interview we can find out that Denis Noble, professor of Cardio-Vascular Physiology, built one of the first models of the heart and recently wrote a very provocative book called "Music of Life" about systems biology. The Videolectures.Net team spoke to him in Dresden at the European Conference on Complex Systems. We asked him about his lecture at the conference, DNA, molecules, meaning of life and how does the organism works. When asked if he moved from applications to philosophy, he answers positively. "Use my book to get rid of some mistakes you may have made by using metaphores of other people, use my metaphores as a contrast, go up the ladder but then throw these away too! Leave yourself, think yourself what you really think biology is about."