HIV continues to infect 14,000 people a day worldwide despite a variety of prevention efforts. In the United States, the rate of infections has hovered at 40,000 a year since 1992, falling far short of the CDC’s goal of reducing HIV infections to 20,000 per year by 2005. This presentation will focus on successful randomized controlled trials for preventing HIV and other STIs in the general population; on whether and how effective prevention measures are actually being used; on what is being done for risk-reduction in persons with HIV infection; and on whether national policies for HIV/STI prevention have been helpful or harmful. From the Series:Science Forum