In this distinguished lecture, David Haussler talks about finding regions of the human genome that are not only under negative selection, but also are specifically evolving like protein-coding regions in genes. Haussler also investigates genetic innovations specific to primates and specific to humans. Given this as a base, and enough well-placed primate genomes to reconstruct intermediate states, scientists should eventually be able to document most of the genomic changes that occurred in the evolution of the human lineage from the mammalian ancestor over the last 80 million years. From the Series:CSE Colloquia - 2005