Dr Lucas Minig discusses a pilot study investigating the use of an inter-uterine devise (IUD) to treat young women with atypical endometrial hyperplasia (AEH) or early endometrial cancer limited to the endometrium. The Mirena IUD is a coil that releases a low dose of the progesterone hormone levonorgestrel. Whereas patients would usually undergo a hysterectomy, use of the IUD is desirable for younger women who wish to become pregnant in the future. Patients were treated with the IUD for one year and received monthly injections with a GnRH analogue for six months. If the cancer stopped growing or did not recur, the device was removed to enable the women plan for pregnancies. The IUD produced a complete response in 97% of patients with AED and 60% of those with endometrial cancer.