The two Friends stars reportedly had a falling out over the way Courteney’s been treating David Arquette since their breakup. NOW HERE'S A HOLLYWOOD SPLIT WE NEVER SAW COMING! JENNIFER ANISTON AND COURTENEY COX? THEY'VE BEEN BFF'S EVER SINCE "FRIENDS", BUT NOW IT LOOKS LIKE ONE OF HOLLYWOOD'S LONGEST RELATIONSHIPS COULD BE ON THE ROCKS. RUMOR HAS IT, JEN'S UPSET THAT COURTENEY IS TREATING DAVID ARQUETTE THE SAME WAY BRAD PITT TREATED HER, BACK WHEN BRAD DUMPED HER AND STARTED HOOKING UP WITH ANGELINA JOLIE. A SOURCE TELLS US WEEKLY THAT, "Jen thinks Courteney is acting callous by running around with HER COUGAR TOWN COSTAR [Brian]VAN HOLT, but refusing to file divorce papers." JEN WAS HEARTBROKEN WHEN BRAD STARTED DATING ANGELINA RIGHT AFTER THEY SPLIT, AND ISN'T DIGGING THAT COURTENEY'S NOW DOING THE SAME THING TO DAVID. THE SOURCE SAYS, "Courteney justifies it by saying she didn't sleep with Brian before she and David separated, but Brad said that about Angelina." WHILE THEIR MARRIAGES MAY NOT HAVE GONE THE DISTANCE, SOMETHING TELLS US, THESE BESTIES ARE GONNA GET PAST THIS...