(CIT): Life is almost synonymous with autonomous movement; indeed, nature has engineered a number of exquisite mechanisms on molecular, cellular and organismal level to accomplish motility on a range of length and time scales. This leads to the question of the chemical and physical basis of motility and its quantitative description. To uncover the basic features of this rich landscape, I will focus on paradigmatic examples of motility including collective mechanochemistry of macromolecular assemblies and molecular motors at the cellular level, to the water driven movements in fungi and plants, to the cell driven movements in morphogenesis, to the muscle driven movements of snakes and fishes. I hope to show how quantitative experiments, physical analogies and simple mathematical models complement comparative studies and allow us to glean design principles in biological systems, which are constrained by physics and engineered by evolution. WALS.