Resident Evil: Afterlife picks up where the third film left off. Since the events of Resident Evil: Extinction, Alice has been roaming the world searching for any remaining survivors. As she enters the ruined Los Angeles, she stumbles onto a prison surrounded by zombies. She then teams up with a group of survivors who had been hiding in Los Angeles since the T-Virus outbreak and helps them break out other survivors held within the jail which include Claire’s brother Chris Redfield.