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MrWhy.com » Videos » Genome-wide discovery of post-translational modulators of transcriptional interactions in human B lymphocytes [electronic resource] / Andrea Califano. |
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Genome-wide discovery of post-translational modulators of transcriptional interactions in human B lymphocytes [electronic resource] / Andrea Califano.
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Genome-wide discovery of post-translational modulators of transcriptional interactions in human B lymphocytes [electronic resource] / Andrea Califano.
(CIT): Transcriptional interactions in the cell are modulated by a variety of mechanisms that prevent their representation as pairwise interactions between a transcription factor and its targets. These include, among others, transcription factor modification by phosphorylation and acetylation, formation of active complexes with one or more transcriptional co-factors, and protein specific degradation and stabilization processes. We introduce a method for the genome-wide computational inference of post-translational modulators of a transcription factor, which are able to affect the ability of the TF to activate/repress its targets. This information theoretic method, MINDY, directly analyzes the multivariate statistical dependencies between a transcription factor and one or more of its targets, conditional on the presence (or absence) of a candidate modulator gene. For more information, visit
Video Length: 66
Date Found: November 19, 2008
Date Produced:
View Count: 16
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