Nancy Lin discusses the session she chaired at the 2010 San Antonio Breast Cancer Symposium on metastases in breast cancer, and specifically her talk on trying to tackle cancer that has spread to the central nervous system by chemotherapy and targeted therapies. Also taking into account the type of breast cancer, e.g. HER 2 positive or triple negative and the life expectancy. Patupilone and ANG1005 are also used to cross the blood brain barrier, increasing efficacy of treatment.